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Article

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.

Human molecular genetics - 1 Feb 2001

Weng L P, Gimm O, Kum J B, Smith W M, Zhou X P, Wynford-Thomas D, Leone G, Eng C

Abstract excerpt

The tumour suppressor gene PTEN/MMAC1/TEP1 has been implicated in a variety of human cancers and several inherited hamartoma tumour syndromes, including Cowden syndrome, which has a high risk of breast and thyroid cancer. We have previously reported that overexpression of PTEN in MCF-7 breast cancer cells induces cell cycle arrest and apoptosis. In this study, we analysed PTEN status at both the structural and...

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Source

Identifiers

PMID: 11159944
DOI: 10.1093/hmg/10.3.251

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.PMID 11159944Read ↗

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Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.Semantic proximity Read ↗

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