Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors.

Cancer - 1 Nov 2008

Hou Peng, Ji Meiju, Xing Mingzhao

Abstract excerpt

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays an important role in thyroid tumorigenesis and progression. Genetic alterations, particularly PIK3CA amplification and mutations and ras mutations, are the major cause of aberrant activation of this pathway in thyroid tumors. Epigenetic silencing of the PTEN gene, a negative regulator of the PI3K/AKT pathway, also occurs in thyroid tumors, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Follicular
Share to Adenoma
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Share to Thyroid Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 18831514
DOI: 10.1002/cncr.23869

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors.PMID 18831514Read ↗

Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer.Semantic proximity Read ↗

Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer.Semantic proximity Read ↗

Gene Methylation in Thyroid TumorigenesisSemantic proximity Read ↗

Uncommon Mutation, but Common Amplifications, of the<i>PIK3CA</i>Gene in Thyroid TumorsSemantic proximity Read ↗

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.Semantic proximity Read ↗

Enhanced protein kinase B/Akt signalling in pituitary tumours.Semantic proximity Read ↗

Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers.Semantic proximity Read ↗

Oncogenic mutations in the TP53 and PI-3 kinase/AKT pathway are independent predictors of survival for advanced thyroid cancer: Analysis from the Molecular Screening and Therapeutics (MoST) program.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.