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Article

Silencing of the <i>PTEN</i> tumor‐suppressor gene in anaplastic thyroid cancer

26 Jul 2002

Abstract excerpt

Germline mutations in the tumor-suppressor gene PTEN (MMAC1, TEP1) are found in Cowden syndrome, which predisposes to hamartomas, breast cancer, trichilemmomas, and thyroid tumors of follicular epithelium. PTEN has also been found to be somatically deleted, mutated, and/or silenced in various sporadically occurring cancers such as glioblastoma, breast cancer, kidney cancer, malignant melanoma, and endometrial...

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Identifiers

PMID: 12203792
DOI: 10.1002/gcc.10098

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Silencing of the <i>PTEN</i> tumor‐suppressor gene in anaplastic thyroid cancerPMID 12203792Read ↗

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