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Article

Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.

Clinical pharmacology and therapeutics - 1 Aug 2010

Chen S-H, Pei D, Yang W, Cheng C, Jeha S, Cox N J, Evans W E, Pui C-H, Relling M V

Abstract excerpt

The genetic variations that result in allergy to asparaginase are as yet undetermined. We interrogated more than 500,000 single-nucleotide polymorphisms (SNPs) in 485 children with acute lymphoblastic leukemia (ALL), 322 in a discovery cohort, and 163 in a validation cohort. In the top 100 SNPs associated with allergy in the discovery cohort, chromosome 5 was overrepresented as compared with other chromosomes (P...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 5

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Source

Open in PubMed Open full text

Identifiers

PMID: 20592726
DOI: 10.1038/clpt.2010.94
PMCID: PMC3000799

Genes

GRIA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.PMID 20592726Read ↗

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