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Article

An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations.

Proteomics - 1 Feb 2016

Makowski Matthew M, Willems Esther, Fang Jun, Choi Jiyeon, Zhang Tongwu, Jansen Pascal W T C, Brown Kevin M, Vermeulen Michiel

Abstract excerpt

Aberrant telomerase reactivation in differentiated cells represents a major event in oncogenic transformation. Recurrent somatic mutations in the human telomerase reverse transcriptase (TERT) promoter region, predominantly localized to two nucleotide positions, are highly prevalent in many cancer types. Both mutations create novel consensus E26 transformation-specific (ETS) motifs and are associated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26553150
DOI: 10.1002/pmic.201500327

Genes

TERT
ELF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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