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Article

Humanin variants aggregate to produce different fibril morphologies.

The Journal of biological chemistry - 1 Jul 2025

Morris Daniel L, Nyenhuis Sarah B, Gruschus James M, Nyenhuis David A, Puja Rashmi, Hinshaw Jenny E, Tjandra Nico

Abstract excerpt

Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX. The therapeutic benefits of HN have been well-documented, and administering humanin and related endogenous human peptides for treatment of disease, aging, and enhancement of athletic performance is becoming more widespread. However, very little is known about the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Microscopy, Electron, Transmission

Share to Protein Aggregates

Share to Protein Conformation, beta-Strand

Share to Protein Structure, Secondary

Share to Proto-Oncogene Proteins c-bcl-2

Source

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Identifiers

PMID: 40543583
DOI: 10.1016/j.jbc.2025.110403
PMCID: PMC12281593

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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