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ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles

13 May 2015

Abstract excerpt

BACKGROUND: Tumour samples containing distinct sub-populations of cancer and normal cells present challenges in the development of reproducible biomarkers, as these biomarkers are based on bulk signals from mixed tumour profiles. ISOpure is the only mRNA computational purification method to date that does not require a paired tumour-normal sample, provides a personalized cancer profile for each patient, and has...

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PMID: 25972088
DOI: 10.1186/s12859-015-0597-x

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