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DeMix: deconvolution for mixed cancer transcriptomes using raw measured data

27 May 2013

Abstract excerpt

MOTIVATION: Tissue samples of tumor cells mixed with stromal cells cause underdetection of gene expression signatures associated with cancer prognosis or response to treatment. In silico dissection of mixed cell samples is essential for analyzing expression data generated in cancer studies. Currently, a systematic approach is lacking to address three challenges in computational deconvolution: (i) violation of...

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PMID: 23712657
DOI: 10.1093/bioinformatics/btt301

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