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GBMPurity: A machine learning tool for estimating glioblastoma tumor purity from bulk RNA-sequencing data

31 Jan 2025

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) presents a significant clinical challenge due to its aggressive nature and extensive heterogeneity. Tumor purity, the proportion of malignant cells within a tumor, is an important covariate for understanding the disease, having direct clinical relevance or obscuring signal of the malignant portion in molecular analyses of bulk samples. However, current methods for estimating tumor...

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PMID: 39891579
DOI: 10.1093/neuonc/noaf026

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