Vascular permeability in cerebral cavernous malformations.

doi:10.1038/jcbfm.2015.98

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Article

Vascular permeability in cerebral cavernous malformations.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Oct 2015

Mikati Abdul G, Khanna Omaditya, Zhang Lingjiao, Girard Romuald, Shenkar Robert, Guo Xiaodong, Shah Akash, Larsson Henrik B W, Tan Huan, Li Luying, Wishnoff Matthew S, Shi Changbin, Christoforidis Gregory A, Awad Issam A

Abstract excerpt

Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observational study investigated whether the brains of human subjects with familial CCM show vascular hyperpermeability by...

Topics

Adolescent
Adult
Aged
Aging
Biomarkers
Brain Ischemia
Capillary Permeability
Cerebrovascular Circulation
Child
Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genotype

Hemangioma, Cavernous, Central Nervous System

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Image Processing, Computer-Assisted

Magnetic Resonance Imaging

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 25966944
DOI: 10.1038/jcbfm.2015.98
PMCID: PMC4640319

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25966944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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