Article
Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution.
Neurosurgical focus - 1 Sept 2010
Yadla Sanjay, Jabbour Pascal M, Shenkar Robert, Shi Changbin, Campbell Peter G, Awad Issam A
Abstract excerpt
Tremendous insight into the molecular and genetic pathogenesis of cerebral cavernous malformations (CCMs) has been gained over the past 2 decades. This includes the identification of 3 distinct genes involved in familial CCMs. Still, a number of unanswered questions regarding the process from gen...
Topics
- Apoptosis Regulatory Proteins
- Capillary Permeability
- Carrier Proteins
- Endothelium, Vascular
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Intercellular Junctions
- Intracranial Arteriovenous Malformations
- KRIT1 Protein
- Membrane Proteins
- Microtubule-Associated Proteins
- Mutation
- Neovascularization, Pathologic
- Proto-Oncogene Proteins