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Article

Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.

International journal of molecular sciences - 30 Apr 2022

Phillips Chelsea M, Stamatovic Svetlana M, Keep Richard F, Andjelkovic Anuska V

Abstract excerpt

Cerebral cavernous malformation (CCM) is a cerebromicrovascular disease that affects up to 0.5% of the population. Vessel dilation, decreased endothelial cell-cell contact, and loss of junctional complexes lead to loss of brain endothelial barrier integrity and hemorrhagic lesion formation. Leaka...

Topics

Animals
Hemangioma, Cavernous, Central Nervous System
Mice
Microtubule-Associated Proteins
Models, Animal
Mutation
Proto-Oncogene Proteins
Zebrafish

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35563390
DOI: 10.3390/ijms23095000
PMCID: PMC9105545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-35563390-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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