Article
Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2020
Wang Kang, Zhang Haifeng, He Yun, Jiang Quan, Tanaka Yoshiaki, Park In-Hyun, Pober Jordan S, Min Wang, Zhou Huanjiao Jenny
Abstract excerpt
OBJECTIVE: Cerebral cavernous malformations (CCM), consisting of dilated capillary channels formed by a single layer of endothelial cells lacking surrounding mural cells. It is unclear why CCM lesions are primarily confined to brain vasculature, although the 3 CCM-associated genes (CCM1, CCM2, an...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Brain
- Cell Communication
- Cell Movement
- Cells, Cultured
- Coculture Techniques
- Endothelial Cells
- Female
- Focal Adhesions
- Gene Deletion
- Genetic Predisposition to Disease
- Hemangioma, Cavernous, Central Nervous System