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Article

Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2020

Wang Kang, Zhang Haifeng, He Yun, Jiang Quan, Tanaka Yoshiaki, Park In-Hyun, Pober Jordan S, Min Wang, Zhou Huanjiao Jenny

Abstract excerpt

OBJECTIVE: Cerebral cavernous malformations (CCM), consisting of dilated capillary channels formed by a single layer of endothelial cells lacking surrounding mural cells. It is unclear why CCM lesions are primarily confined to brain vasculature, although the 3 CCM-associated genes (CCM1, CCM2, and CCM3) are ubiquitously expressed in all tissues. We aimed to determine the role of CCM gene in brain mural cell in...

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PMID: 32640906
DOI: 10.1161/ATVBAHA.120.314586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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