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Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling

17 Sept 2012

Abstract excerpt

Cerebral cavernous malformation (CCM) involves the homozygous inactivating mutations of one of three genes, ccm1, -2, or -3 resulting in hyperpermeable blood vessels in the brain. The CCM1, -2, and -3 proteins form a complex to organize the signaling networks controlling endothelial cell physiology including actin dynamics, tube formation, and adherens junctions. The common biochemical defect with the loss of...

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PMID: 23096573
DOI: 10.1515/hsz-2012-0243

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