Article
Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2011
Louvi Angeliki, Chen Leiling, Two Aimee M, Zhang Haifeng, Min Wang, Günel Murat
Abstract excerpt
Communication between neural cells and the vasculature is integral to the proper development and later function of the central nervous system. A mechanistic understanding of the interactions between components of the neurovascular unit has implications for various disorders, including cerebral ca...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Astrocytes
- Blood Vessels
- Cell Proliferation
- Cell Survival
- Glial Fibrillary Acidic Protein
- Hemangioma, Cavernous, Central Nervous System
- Membrane Proteins
- Mice
- Mice, Neurologic Mutants
- Neuroglia
- Phenotype
- Sequence Analysis, RNA