Article
Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype.
The FEBS journal - 1 Mar 2010
Chan Aubrey C, Li Dean Y, Berg Michel J, Whitehead Kevin J
Abstract excerpt
Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurologic deficits and potentially fatal hemorrhagic stroke. Human genetic studies have identified three genes associated with the disease and biochemical studies of these proteins have identified interaction partners and possible signaling pathways. A variety of animal models of CCM have...
Topics
- Animals
- Disease Models, Animal
- Genetic Predisposition to Disease
- Hemangioma, Cavernous, Central Nervous System
- Humans
- KRIT1 Protein
- Microfilament Proteins
- Microtubule-Associated Proteins
- Phenotype
- Proto-Oncogene Proteins