Article
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Retta Saverio Francesco, Perrelli Andrea, Trabalzini Lorenza, Finetti Federica
Abstract excerpt
Cerebral cavernous malformation (CCM) is a rare cerebrovascular disorder of genetic origin consisting of closely clustered, abnormally dilated and leaky capillaries (CCM lesions), which occur predominantly in the central nervous system. CCM lesions can be single or multiple and may result in severe clinical symptoms, including focal neurological deficits, seizures, and intracerebral hemorrhage. Early human...
Topics
- Alleles
- Animals
- Biomarkers
- Disease Management
- Disease Models, Animal
- Genetic Association Studies
- Genetic Predisposition to Disease
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Magnetic Resonance Imaging