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Article

Genetic alterations of DNA methylation machinery in human diseases.

Epigenomics - 1 Jan 2015

Hamidi Tewfik, Singh Anup Kumar, Chen Taiping

Abstract excerpt

DNA methylation plays a critical role in the regulation of chromatin structure and gene expression and is involved in a variety of biological processes. The levels and patterns of DNA methylation are regulated by both DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) and 'demethylating' proteins, including the ten-eleven translocation (TET) family of dioxygenases (TET1, TET2 and TET3). The effects of DNA...

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Source

Identifiers

PMID: 25942534
DOI: 10.2217/epi.14.80

Genes

DNMT1
TET1
TET2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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