Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.

Seminars in neurology - 1 Jul 2014

Weissman Jacqueline, Naidu Sakkubai, Bjornsson Hans T

Abstract excerpt

Recently, Mendelian disorders of the DNA methylation machinery have been described which demonstrate the complex roles of epigenetics in neurodevelopment and disease. For example, defects of DNMT1, the maintenance methyltransferase, lead to adult-onset progressive neurologic disorders, whereas defects of the de novo methyltransferases DNMT3A and DNMT3B lead to nonprogressive neurodevelopmental conditions....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3B

Share to Epigenesis, Genetic

Share to DNMT1 gene

Share to Genetic Predisposition to Disease

Share to Intelligence

Share to Nervous System Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 25192503
DOI: 10.1055/s-0034-1386763
PMCID: PMC4512289

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.PMID 25192503Read ↗

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disordersSemantic proximity Read ↗

Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders.Semantic proximity Read ↗

Genetic alterations of DNA methylation machinery in human diseases.Semantic proximity Read ↗

Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment.Semantic proximity Read ↗

Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research.Semantic proximity Read ↗

Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficitsSemantic proximity Read ↗

Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits.Semantic proximity Read ↗

Interplay between Histone and DNA Methylation Seen through Comparative Methylomes in Rare Mendelian Disorders.Semantic proximity Read ↗

The molecular pathology of Rett syndrome: synopsis and update.Semantic proximity Read ↗

Germline Abnormalities in DNA Methylation and Histone Modification and Associated Cancer Risk.Semantic proximity Read ↗

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.Semantic proximity Read ↗

Rett syndrome: a surprising result of mutation in MECP2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.