Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome mis-segregation and cytokinesis failure in trisomic human cells.

eLife - 5 May 2015

Nicholson Joshua M, Macedo Joana C, Mattingly Aaron J, Wangsa Darawalee, Camps Jordi, Lima Vera, Gomes Ana M, Dória Sofia, Ried Thomas, Logarinho Elsa, Cimini Daniela

Abstract excerpt

Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To test the effects of aneuploidy on chromosome segregation and other mitotic phenotypes we used the colorectal cancer cell line DLD1 (2n = 46) and two variants with trisomy 7 or 13 (DLD1+7 and DLD1+13), as well as euploid and trisomy 13 amniocytes (AF and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amniotic Fluid
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 13

Share to Chromosomes, Human, Pair 7

Share to Cytokinesis

Share to Primary Cell Culture

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 25942454
DOI: 10.7554/eLife.05068
PMCID: PMC4443816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome mis-segregation and cytokinesis failure in trisomic human cells.PMID 25942454Read ↗

Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.Semantic proximity Read ↗

Chromosomal Aneuploidy Affects the Global Proteome Equilibrium of Colorectal Cancer CellsSemantic proximity Read ↗

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read ↗

Depletion of aneuploid cells is shaped by cell-to-cell interactionsSemantic proximity Read ↗

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stabilitySemantic proximity Read ↗

Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer.Semantic proximity Read ↗

New Cell Cycle Inhibitors Target Aneuploidy in Cancer TherapySemantic proximity Read ↗

Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and MeiosisSemantic proximity Read ↗

FOXM1 is critical for the fitness recovery of chromosomally unstable cellsSemantic proximity Read ↗

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome AberrationsSemantic proximity Read ↗

Deregulation of Chromosome Segregation and CancerSemantic proximity Read ↗

Non-Random Mis-Segregation of Human ChromosomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.