Article
Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer.
In vivo (Athens, Greece) - 1 Jan 2000
Wenzel Elizabeth S, Singh Amareshwar T K
Abstract excerpt
The cell cycle is a complex sequence of events through which a cell duplicates its contents and divides, and involves many regulatory proteins for proper cellular reproduction, including cyclin proteins and cyclin-dependent kinases, oncogenes and tumor-suppressor genes, and mitotic checkpoint proteins. Mutations of any of these regulatory mechanisms can lead to reproduction of cells carrying genetic mutations or...
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