Article

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

2021-08-31

Abstract excerpt

Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneuploidy per se is sufficient to drive CIN, however due to limited models and heterogenous results, it has remained controversial which aspects of aneuploidy can drive C...

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Literature Corpus work: 9f6b0cf6-ef80-51b9-93fd-12d8a44e5db9
DOI: 10.1101/2021.08.31.458318

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