Article
The genetics of lupus.
Current opinion in nephrology and hypertension - 1 May 2001
Yim Y S, Wakeland E K
Abstract excerpt
The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that impact on specific checkpoints in a three-step pathogenic pathway. These steps are as follows:...
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