Mendelian Causes of Autoimmunity: the Lupus Phenotype.

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by its large heterogeneity in terms of clinical presentation and severity. The pathophysiology of SLE involves an aberrant autoimmune response against various tissues, an excess of apoptotic bodies, and an overproduction of type-I interferon. The genetic contribution to the disease is supported by studies of monozygotic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigen-Antibody Complex
• Share to Autoimmunity