Article
Monogenic lupus: Tracing the therapeutic implications from single gene mutations.
Clinical immunology (Orlando, Fla.) - 1 Sept 2023
Jia Xiuzhi, Tan Li, Chen Sixiu, Tang Ruihan, Chen Wei
Abstract excerpt
Monogenic lupus, a distinctive variant of systemic lupus erythematosus (SLE), is characterized by early onset, family-centric clustering, and heightened disease severity. So far, over thirty genetic variations have been identified as single-gene etiology of SLE and lupus-like phenotypes. The critical role of these gene mutations in disrupting various immune pathways is increasingly recognized. In particular,...
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