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Article

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.

Nature neuroscience - 1 Jun 2015

Kim Il Hwan, Rossi Mark A, Aryal Dipendra K, Racz Bence, Kim Namsoo, Uezu Akiyoshi, Wang Fan, Wetsel William C, Weinberg Richard J, Yin Henry, Soderling Scott H

Abstract excerpt

Psychiatric and neurodevelopmental disorders may arise from anomalies in long-range neuronal connectivity downstream of pathologies in dendritic spines. However, the mechanisms that may link spine pathology to circuit abnormalities relevant to atypical behavior remain unknown. Using a mouse model to conditionally disrupt a critical regulator of the dendritic spine cytoskeleton, the actin-related protein 2/3...

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Identifiers

PMID: 25938885
DOI: 10.1038/nn.4015
PMCID: PMC4459733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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