Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.

Cell reports - 23 Aug 2016

Managò Francesca, Mereu Maddalena, Mastwal Surjeet, Mastrogiacomo Rosa, Scheggia Diego, Emanuele Marco, De Luca Maria A, Weinberger Daniel R, Wang Kuan Hong, Papaleo Francesco

Abstract excerpt

Human genetic studies have recently suggested that the postsynaptic activity-regulated cytoskeleton-associated protein (Arc) complex is a convergence signal for several genes implicated in schizophrenia. However, the functional significance of Arc in schizophrenia-related neurobehavioral phenotypes and brain circuits is unclear. Here, we find that, consistent with schizophrenia-related phenotypes, disruption of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amphetamine
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Agonists

Share to Dopamine Antagonists

Share to Prefrontal Cortex

Share to Psychomotor Disorders

Share to Receptors, Dopamine D1

Share to Sensory Gating

Source

Open in PubMed Open full text

Identifiers

PMID: 27524619
DOI: 10.1016/j.celrep.2016.07.044
PMCID: PMC5001893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.PMID 27524619Read ↗

RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.Semantic proximity Read ↗

Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in rats.Semantic proximity Read ↗

Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.Semantic proximity Read ↗

Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region.Semantic proximity Read ↗

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.Semantic proximity Read ↗

Activity‐regulated cytoskeleton‐associated protein (Arc/Arg3.1) regulates anxiety‐ and novelty‐related behaviorsSemantic proximity Read ↗

TMEM16A ablation in cholinergic medial habenula neurons induces early-onset schizophrenia-like phenotypes in mice.Semantic proximity Read ↗

Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.Semantic proximity Read ↗

Alterations in amphetamine-stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and postweaning isolation.Semantic proximity Read ↗

The MAM Rodent Model of SchizophreniaSemantic proximity Read ↗

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia ModelSemantic proximity Read ↗

Behavioral genetic contributions to the study of addiction-related amphetamine effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.