Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009

Cahill Michael E, Xie Zhong, Day Michelle, Photowala Huzefa, Barbolina Maria V, Miller Courtney A, Weiss Craig, Radulovic Jelena, Sweatt J David, Disterhoft John F, Surmeier D James, Penzes Peter

Abstract excerpt

Dendritic spine morphogenesis contributes to brain function, cognition, and behavior, and is altered in psychiatric disorders. Kalirin is a brain-specific guanine-nucleotide exchange factor (GEF) for Rac-like GTPases and is a key regulator of spine morphogenesis. Here, we show that KALRN-knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Spines

Share to Frontal Lobe

Share to Guanine Nucleotide Exchange Factors

Share to Maze Learning

Share to Motor Activity

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 19625617
DOI: 10.1073/pnas.0904636106
PMCID: PMC2722269

Genes

KALRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19625617-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.PMID 19625617Read ↗

Hippocampal phenotypes in kalirin-deficient mice.Semantic proximity Read ↗

A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.Semantic proximity Read ↗

A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across DevelopmentSemantic proximity Read ↗

Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.Semantic proximity Read ↗

MARK1 regulates dendritic spine morphogenesis and cognitive functions <i>in vivo</i>Semantic proximity Read ↗

Dendritic structural plasticity and neuropsychiatric disease.Semantic proximity Read ↗

Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmissionSemantic proximity Read ↗

HACE1 deficiency leads to structural and functional neurodevelopmental defectsSemantic proximity Read ↗

Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7.Semantic proximity Read ↗

KIBRA Regulates AMPA Receptor Expression, Synaptic Plasticity, and Memory in an Age-Dependent MannerSemantic proximity Read ↗

Distinct and Complementary Functions of Rho kinase isoforms ROCK1 and ROCK2 in Prefrontal Cortex Structural PlasticitySemantic proximity Read ↗

Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.