Article
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.
Translational psychiatry - 17 Dec 2013
Manitt C, Eng C, Pokinko M, Ryan R T, Torres-Berrío A, Lopez J P, Yogendran S V, Daubaras M J J, Grant A, Schmidt E R E, Tronche F, Krimpenfort P, Cooper H M, Pasterkamp R J, Kolb B, Turecki G, Wong T P, Nestler E J, Giros B, Flores C
Abstract excerpt
Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to...
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