Article

Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Human genetics indicates enrichment of synaptic pathway-related mutations in Autism Spectrum Disorder (ASD). Accordingly, several preclinical studies have reported synaptic alterations in different brain areas of relevant ASD mouse models. In particular, we previously showed that corticostriatal long-term synaptic depression is impaired in the dorsal striatum of mice carrying the ASD-as...

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Literature Corpus work: b43f81ef-7d63-5876-82df-2f41cd2fc3aa
DOI: 10.21203/rs.3.rs-4893764/v2

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