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Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond

14 Jul 2022

Abstract excerpt

Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans' foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations of genetic alterations (GA) in GBM induce a diversity of metabolic phenotypes resulting in enhanced malignancy and altered sensitivity to current therapies. Furthermore, GA as a hallmark of cancer, dysregulated cell metabolism in GBM has...

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PMID: 35912242
DOI: 10.3389/fonc.2022.901951

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