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Article

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme

9 Dec 2016

Abstract excerpt

Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastoma multiforme (GBM) progression. In response to hypoxia, GBM cells are able to express a transcription factor called hypoxia inducible factor-1 (HIF-1). HIF-1 belongs to a family of heterodimeric proteins that includes HIF-1α and HIF-1β subunits. HIF-1α has been reported to play a pivotal role in GBM development and...

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PMID: 27959421
DOI: 10.3892/or.2016.5309

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