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Article

Glucose-6-phosphatase is a key metabolic regulator of glioblastoma invasion.

Molecular cancer research : MCR - 1 Nov 2014

Abbadi Sara, Rodarte Julio J, Abutaleb Ameer, Lavell Emily, Smith Chris L, Ruff William, Schiller Jennifer, Olivi Alessandro, Levchenko Andre, Guerrero-Cazares Hugo, Quinones-Hinojosa Alfredo

Abstract excerpt

UNLABELLED: Glioblastoma (GBM) remains the most aggressive primary brain cancer in adults. Similar to other cancers, GBM cells undergo metabolic reprogramming to promote proliferation and survival. Glycolytic inhibition is widely used to target such reprogramming. However, the stability of glycolytic inhibition in GBM remains unclear especially in a hypoxic tumor microenvironment. In this study, it was determined...

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Source

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Identifiers

PMID: 25001192
DOI: 10.1158/1541-7786.MCR-14-0106-T
PMCID: PMC4233174

Genes

GYS1
PYGL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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