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Article

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.

Oncotarget - 19 Jul 2016

Miranda-Gonçalves Vera, Granja Sara, Martinho Olga, Honavar Mrinalini, Pojo Marta, Costa Bruno M, Pires Manuel M, Pinheiro Célia, Cordeiro Michelle, Bebiano Gil, Costa Paulo, Reis Rui M, Baltazar Fátima

Abstract excerpt

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment through monocarboxylate transporters (MCTs). While hypoxia-mediated regulation of MCT4 has been characterized, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27331625
DOI: 10.18632/oncotarget.10114
PMCID: PMC5216802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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