Article
TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.
European journal of immunology - 1 Jun 2015
Villanueva Jeanette E, Malle Elisabeth K, Gardam Sandra, Silveira Pablo A, Zammit Nathan W, Walters Stacey N, Brink Robert, Grey Shane T
Abstract excerpt
In this study, a critical and novel role for TNF receptor (TNFR) associated factor 2 (TRAF2) is elucidated for peripheral CD8(+) T-cell and NKT-cell homeostasis. Mice deficient in TRAF2 only in their T cells (TRAF2TKO) show ∼40% reduction in effector memory and ∼50% reduction in naïve CD8(+) T-cell subsets. IL-15-dependent populations were reduced further, as TRAF2TKO mice displayed a marked ∼70% reduction in...
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