Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity.

Cell reports - 19 Nov 2019

Pfefferle Aline, Jacobs Benedikt, Netskar Herman, Ask Eivind Heggernes, Lorenz Susanne, Clancy Trevor, Goodridge Jodie P, Sohlberg Ebba, Malmberg Karl-Johan

Abstract excerpt

Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive. Here, we show that subset-specific NK cell proliferation kinetics correlate with mTOR activation, and global repertoire diversity is maintained through a high degree of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD56 Antigen
Share to CD57 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-15

Share to Killer Cells, Natural

Share to NF-kappa B

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Sequence Analysis, RNA

Share to Synapses

Source

Identifiers

PMID: 31747601
DOI: 10.1016/j.celrep.2019.10.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity.PMID 31747601Read ↗

Diversity of human NK cell developmental pathways defined by single-cell analyses.Semantic proximity Read ↗

T-BET and EOMES sustain mature human NK cell identity and antitumor functionSemantic proximity Read ↗

Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8+ T Cells.Semantic proximity Read ↗

Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral BloodSemantic proximity Read ↗

Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulationSemantic proximity Read ↗

TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype.Semantic proximity Read ↗

A Temporal Transcriptional Map of Human Natural Killer Cell DifferentiationSemantic proximity Read ↗

Natural Killer Cells: From Innate to Adaptive FeaturesSemantic proximity Read ↗

Unraveling exhaustion in adaptive and conventional NK cellsSemantic proximity Read ↗

NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.Semantic proximity Read ↗

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.Semantic proximity Read ↗

Emerging insights into natural killer cells in human peripheral tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.