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Article

Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells

26 Oct 2015

Abstract excerpt

During infection, naïve CD4(+) T helper cells differentiate into specialized effector subsets based upon environmental signals propagated by the cytokine milieu. Recently, this paradigm has been complicated by the demonstration that alterations in the cytokine environment can result in varying degrees of plasticity between effector T helper cell populations. Therefore, elucidation of the mechanisms by which...

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PMID: 26500048
DOI: 10.1038/srep15722

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