Article
An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
Cell reports - 31 Oct 2023
Johansson Kristina, Gagnon John D, Zhou Simon K, Fassett Marlys S, Schroeder Andrew W, Kageyama Robin, Bautista Rodriel A, Pham Hewlett, Woodruff Prescott G, Ansel K Mark
Abstract excerpt
The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells to mediate a sustained response. Here, we used conditional deletion of miR-15/16 in regulatory T cells (Tregs) to identify immune functions of the miR-15/16 family in T cells....
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