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Article

ITK and IL-15 support two distinct subsets of CD8+ T cells.

Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006

Dubois Sigrid, Waldmann Thomas A, Müller Jürgen R

Abstract excerpt

CD8(+) T cells are commonly divided into naïve CD44(lo)CD122(lo) and "memory phenotype" CD44(hi)CD122(hi) cells. Here we show data suggesting that these two cell populations represent independent CD8(+) T cell subsets. Whereas IL-15(-/-) mice lack CD44(hi)CD122(hi) CD8(+) T cells, mice deficient in the kinase ITK lack CD44(lo)CD122(lo) cells among CD8(+) T cells. The same defects were observed during thymus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16880398
DOI: 10.1073/pnas.0605212103
PMCID: PMC1567699

Genes

ITK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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