Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

Science (New York, N.Y.) - 28 Apr 2000

Ku C C, Murakami M, Sakamoto A, Kappler J, Marrack P

Abstract excerpt

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hyaluronan Receptors
Share to Immunologic Memory
Share to Interleukin-15

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-7

Share to Lymphocyte Count

Share to Receptors, Interleukin-2

Share to Receptors, Interleukin-7

Share to Specific Pathogen-Free Organisms

Source

Identifiers

PMID: 10784451
DOI: 10.1126/science.288.5466.675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of homeostasis of CD8+ memory T cells by opposing cytokines.PMID 10784451Read ↗

Antiviral CD4+ memory T cells are IL-15 dependent.Semantic proximity Read ↗

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.Semantic proximity Read ↗

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.Semantic proximity Read ↗

TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.Semantic proximity Read ↗

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.Semantic proximity Read ↗

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.Semantic proximity Read ↗

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.Semantic proximity Read ↗

The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nT(H)17 cell homeostasis in the thymus.Semantic proximity Read ↗

IL-2 inhibited the generation of CD4+ memory T cells.Semantic proximity Read ↗

Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo.Semantic proximity Read ↗

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host diseaseSemantic proximity Read ↗

Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.