Article

TREM2 Promotes Natural Killer Cell Development in CD3-CD122+NK1.1+ pNK Cells

2020-12-29

Abstract excerpt

<h4>Background: </h4> Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity, and Alzheimer’s disease pathogenesis. However, little is known regarding the effect of TREM2 on natural killer (NK) cells. <h4>Results: </h4>: Here, we demonstrated for the first time t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65617f70-ebe9-5687-839c-e29c4f92abab
DOI: 10.21203/rs.3.rs-128819/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TREM2 Promotes Natural Killer Cell Development in CD3-CD122+NK1.1+ pNK CellsDOI 10.21203/rs.3.rs-128819/v1Read

Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.Semantic proximity Read

Diversity of tissue-resident NK cells.Semantic proximity Read

Comprehensive Identification of Trem2 as a Key Factor in Promoting the Progression of Hepatocellular Carcinoma and Predicting PrognosisSemantic proximity Read

Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activitySemantic proximity Read

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases.Semantic proximity Read

Advances in NKG2D ligand recognition and responses by NK cellsSemantic proximity Read

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejectionSemantic proximity Read

NKG2D signaling in cancer immunosurveillanceSemantic proximity Read

Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: a role for the T-cell receptor and natural killer cell receptors.Semantic proximity Read

Transcriptome analysis reveals similarities between human blood CD3− CD56bright cells and mouse CD127+ innate lymphoid cellsSemantic proximity Read

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residencySemantic proximity Read

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.Semantic proximity Read