Article

T cells restrain inflammation driven by TNF-induced cell death

2026-04-23

Abstract excerpt

TNF is a potent proinflammatory cytokine that can induce cell death by activating the kinase RIPK1. The adaptor proteins TANK and AZI2 protect against cell death by recruiting TBK1 to the TNF receptor signaling complex, thereby inhibiting RIPK1. While deficiency of either adaptor alone is well tolerated, combined loss of TANK and AZI2 results in partial embryonic lethality and severe TNF- and RIPK1-driven autoinfl...

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Literature Corpus work: 3c600d72-fa46-570d-9a30-181ab6d3f629
DOI: 10.64898/2026.04.21.719867

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