Article
High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma.
Cancer research - 1 Jul 2015
Udager Aaron M, Rolland Delphine C M, McHugh Jonathan B, Betz Bryan L, Murga-Zamalloa Carlos, Carey Thomas E, Marentette Lawrence J, Hermsen Mario A, DuRoss Kathleen E, Lim Megan S, Elenitoba-Johnson Kojo S J, Brown Noah A
Abstract excerpt
Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm associated with sinonasal squamous cell carcinoma (SNSCC) in 10% to 25% of cases. To date, no recurrent mutations have been identified in ISP or SNSCC. Using targeted next-generation sequencing and Sanger sequencing, we identified activating EGFR mutations in 88% of ISP and 77% of ISP-associated SNSCC. Identical EGFR genotypes were found in...
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