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Article

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing.

International journal of clinical oncology - 1 Oct 2018

Yasukawa Shinichiro, Kano Satoshi, Hatakeyama Hiromitsu, Nakamaru Yuji, Takagi Dai, Mizumachi Takatsugu, Suzuki Masanobu, Suzuki Takayoshi, Nakazono Akira, Tanaka Shinya, Nishihara Hiroshi, Homma Akihiro

Abstract excerpt

BACKGROUND: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. METHODS: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. RESULTS: The number of mutant genes increased in the order of IP < dysplasia < SCC....

Topics

Adult
Aged
Biomarkers, Tumor
Carcinoma, Squamous Cell
Cell Transformation, Neoplastic
DNA Mutational Analysis
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nose Neoplasms

Papilloma, Inverted

Paranasal Sinus Neoplasms

Prognosis

Source

Identifiers

PMID: 29779136
DOI: 10.1007/s10147-018-1296-1

Genes

KRAS
APC
STK11

Provenance

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