EGFR and BRAF mutations in inverted sinonasal papilloma - a more complex landscape?

doi:10.1007/s00428-020-02945-y

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Article

EGFR and BRAF mutations in inverted sinonasal papilloma - a more complex landscape?

Virchows Archiv : an international journal of pathology - 1 May 2021

Zonnur Sarah, Erbersdobler Andreas, Schneider Björn

Abstract excerpt

Inverted (Schneiderian) sinonasal papilloma (ISP) is a neoplasm derived from mucosa of the sinonasal tract characterized by local aggressive growth, a tendency to recur and an association with sinonasal carcinoma. The etiology of ISP remains unclear. Recently, identical mutations in exons 19 and 20 of the oncogene EGFR were reported in ISP and ISP-associated sinonasal carcinoma. Nevertheless, it remains unclear...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
DNA Mutational Analysis
ErbB Receptors
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Papilloma, Inverted

Paranasal Sinus Neoplasms

Phenotype

Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 33048186
DOI: 10.1007/s00428-020-02945-y
PMCID: PMC8286953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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