Article
Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Feb 2018
Udager A M, McHugh J B, Goudsmit C M, Weigelin H C, Lim M S, Elenitoba-Johnson K S J, Betz B L, Carey T E, Brown N A
Abstract excerpt
Background: Inverted sinonasal (Schneiderian) papilloma (ISP) is a locally aggressive neoplasm often associated with sinonasal squamous cell carcinoma (SNSCC). While the etiology of ISP is not well understood, human papillomavirus (HPV) has been detected in a subset of cases. Our group recently identified activating somatic EGFR mutations in the majority of ISP and ISP-associated SNSCC. However, the relationship...
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