Article
Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion.
Histopathology - 1 Dec 2018
Sasaki Eiichi, Nishikawa Daisuke, Hanai Nobuhiro, Hasegawa Yasuhisa, Yatabe Yasushi
Abstract excerpt
AIMS: Molecular targeted therapy against EGFR kinase domain mutations has been successfully established for lung cancer. These mutations have now also been reported in head and neck tumours, particularly in inverted sinonasal papillomas (ISPs). The aim of this study was to clarify the spectrum of EGFR mutations in head and neck squamous cell carcinomas and papillomas. METHODS AND RESULTS: We examined EGFR...
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