Article
Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma.
The Journal of pathology - 1 Aug 2016
Udager Aaron M, McHugh Jonathan B, Betz Bryan L, Montone Kathleen T, Livolsi Virginia A, Seethala Raja R, Yakirevich Evgeny, Iwenofu O Hans, Perez-Ordonez Bayardo, DuRoss Kathleen E, Weigelin Helmut C, Lim Megan S, Elenitoba-Johnson Kojo Sj, Brown Noah A
Abstract excerpt
Oncocytic sinonasal papillomas (OSPs) are benign tumours of the sinonasal tract, a subset of which are associated with synchronous or metachronous sinonasal squamous cell carcinoma (SNSCC). Activating EGFR mutations were recently identified in nearly 90% of inverted sinonasal papillomas (ISPs) - a related tumour with distinct morphology. EGFR mutations were, however, not found in OSP, suggesting that different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.