Article
TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2021
Brown Noah A, Plouffe Komal R, Yilmaz Osman, Weindorf Steven C, Betz Bryan L, Carey Thomas E, Seethala Raja R, McHugh Jonathan B, Tomlins Scott A, Udager Aaron M
Abstract excerpt
Sinonasal papillomas are benign epithelial tumors of the sinonasal tract that are associated with a synchronous or metachronous sinonasal carcinoma in a subset of cases. Our group recently identified mutually exclusive EGFR mutations and human papillomavirus (HPV) infection in inverted sinonasal papillomas and frequent KRAS mutations in oncocytic sinonasal papillomas. We also demonstrated concordant mutational...
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