Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.

doi:10.1038/tpj.2012.36

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Article

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.

The pharmacogenomics journal - 1 Dec 2013

Berce V, Kozmus C E P, Potočnik U

Abstract excerpt

Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene region on the response to antiasthmatic treatment with inhaled corticosteroids (ICSs) and ORMDL3 gene expression. Forced expiratory volume in 1 s increased significantly by 13.3%...

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Identifiers

PMID: 22986918
DOI: 10.1038/tpj.2012.36

Genes

ORMDL3
ORM1

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Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.PMID 22986918Read ↗

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